venofer dosing calculator

In key trials, ferric carboxymaltose increased Hb levels and replenished iron stores as effectively as IV iron sucrose . Avoid or Use Alternate Drug. Minor (2)calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. Am J Hosp Pharm. lansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Use Caution/Monitor. Administer Venofer only intravenously by slow injection or by infusion. Minor/Significance Unknown. Intravenous iron-dextran: therapeutic and experimental possibilities [in German] Schweiz Med Wochenschr. Applies only to oral form of both agents. This site contains information for licensed healthcare professionals in the United States. Crown Rump Length and Nuchal Translucency. Use Caution/Monitor. Serious - Use Alternative (1)iron sucrose decreases levels of doxycycline by inhibition of GI absorption. Patients diagnosed with iron deficiency are prescribed iron supplementation, either to replete body stores or to correct anemia. Applies only to oral form of both agents. Applies only to oral form of both agents. Venofer (iron sucrose injection, USP) For Intravenous Use Only INDICATION AND USAGE Venofer (iron sucrose injection, USP) is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Inspect parenteral drug products visually for the absence of particulate matter and discoloration prior to administration. Applies only to oral form of both agents. Applies only to oral form of both agents. Next Steps Evidence Creator Insights Dr. Andreas M. Ganzoni About the Creator https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=abacb7fa-2fc2-471e-9200-944eeac8ca2a. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. 1 Dosing for patients who weigh less than 50 kg Controlled studies in pregnant women show no evidence of fetal risk. By taking into account the case of a patient weighing 78 kg (172 lbs) and having a hemoglobin level of 11 g/dL (110 g/L or 6.83 mmol/L). Minor/Significance Unknown. Copyright 2021 GlobalRPH - Web Development by, Calculation of the Total Iron Deficit Alternative equation. 4)Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK, Roger SD, Savoia HF, Tampi R, Thomson AR, Wood EM, Robinson KL. 4) Gozzard D. (2011) When is high-dose intravenous iron repletion needed? There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14. 3. Anemia. Monitor Closely (1)iron sucrose will decrease the level or effect of omadacycline by inhibition of GI absorption. Dosage: For patients weighing 50 kg (110 lb) or more: Give Injectafer in two doses separated by at least 7 days. Separate by 2 hr. This drug is available at a higher level co-pay. USES: This medicine is used to treat "iron-poor" blood (anemia) in people with long-term kidney disease. Avoid or Use Alternate Drug. Uses for Iron Sucrose Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events. The recommended dosage of iron sucrose for repletion of iron deficiency in patients undergoing hemodialysis is 5ml of iron sucrose (100mg of elemental iron) delivered intravenously during the dialysis session. The two formulas used are presented below: Iron deficit in mg = Weight in kg x (14 Hb in g/dL) x 2.145, Volume of product required in mL = Iron deficit in mg / C in mg/mL. Foods rich in iron include meats (especially liver), eggs, raisins, figs, broccoli, brussels sprouts, beans, lentils, and iron-fortified or enriched cereals. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Administer ciprofloxacin at least 2 hours before or 6 hours after using these products. The recipient will receive more details and instructions to access this offer. Venofer may reduce the absorption of concomitantly administered oral iron preparations. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every four weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Do Not Copy, Distribute or otherwise Disseminate without express permission. Adult Patients: The most common adverse reactions (2%) include diarrhea, nausea, vomiting, headache, dizziness, hypotension, pruritus, pain in extremity, arthralgia, back pain, muscle cramp, injection site reactions, chest pain and peripheral edema. Iron sucrose: 20 mg/mL. Since this is less than the threshold of total dose of 20 mg/kg, the deficit can be eliminated with a single infusion. Please note that once you have closed the PDF you need to click on the Calculate button before you try opening it again, otherwise the input and/or results may not appear in the pdf. Applies only to oral form of both agents. Here are the steps to follow for using this drug dosage calculator: First, enter the value of your Weight and choose the unit of measurement from the drop-down menu. Use Caution/Monitor. Minor (2)calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. in the colostrum of 10 iron deficient breastfeeding women who were 2 to 3 days postpartum and received a single dose of 100 mg of intravenous iron . Serious - Use Alternative (1)iron sucrose decreases levels of tetracycline by inhibition of GI absorption. Both the 200- and 300-mg doses of IV iron sucrose administered over 2 hours appear to be safe. Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session [see How Supplied/Storage and Handling (16.2).] Minor/Significance Unknown. iron sucrose decreases levels of liothyronine by inhibition of GI absorption. Applies only to oral form of both agents. Schweiz Med Wochenschr; 100(7):301-3. sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of iron sucrose by inhibition of GI absorption. For liquid medications, also enter the value of the Medicine Concentration and choose . Administer Venofer early during the dialysis session (generally within the first hour). Shirley, NY: American Regent, Inc.; 9/2020. Minor/Significance Unknown. *Administer early during the dialysis session. Use Caution/Monitor. Indications: Feraheme is indicated for the treatment of iron deficiency anemia (IDA) in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron or who have chronic kidney disease (CKD). US residents can call their local poison control center at 1-800-222-1222. Follow your doctor's directions carefully.Tell your doctor right away if you have any serious side effects, including: abdominal pain, chest pain, irregular heartbeat (arrhythmias), pressure in the chest, severe headache and blurred vision (hypertension), problems with your dialysis access site (graft).A very serious allergic reaction to this drug is unlikely, but get medical help right away if it occurs. Use Caution/Monitor. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. * Calculators are available in UpToDate to determine ideal body weight and lean body weight. Adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Calculation of the Total Iron Deficit Alternative equation, Iron Dextran Dosing Calculator (iron deficit), HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication, Pharmacosmos A/S, CosmoFer low molecular weight (Mw) iron dextran. Symptoms associated with Venofer total dosage or infusing too rapidly included hypotension, dyspnea, headache, vomiting, nausea, dizziness, joint aches, paresthesia, abdominal and muscle pain, edema and cardiovascular collapse. Applies only to oral form of both agents. J Med. iron sucrose decreases levels of minocycline by inhibition of GI absorption. Use Caution/Monitor. Reference www.medicines.org.uk Background By using this form you agree with the storage and handling of your data by this website. Serious - Use Alternative (1)iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. iron sucrose, benazepril. Anaphylaxis may occur with IV iron and resuscitation facilities should be available.11 It would appear that iron polymaltose may have a higher incidence of severe systemic reactions than iron sucrose and ferric carboxymaltose. Modify Therapy/Monitor Closely. In the text below the tool there is more information on how the iron deficit is calculated. Serious - Use Alternative (1)iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. Introduction Uses Dosage Warnings Interactions Stability Introduction Hematinic agent; a polynuclear iron (III)-hydroxide sucrose complex. Excessive dosages of Venofer may lead to accumulation of iron in storage sites potentially leading to hemosiderosis. Applies only to oral form of both agents. Applies only to oral form of both agents. Hemodialysis-dependent CKD: 100 mg elemental iron IV (injection or infusion over 2-5 min) per dialysis session not to exceed total cumulative dose of 1000 mg divided in 3 doses/week. Schweiz Med Wochenschr; 100(7):301-3. If you log out, you will be required to enter your username and password the next time you visit. Avoid or Use Alternate Drug. These adverse reactions have occurred up to 30 minutes after the administration of Venofer injection. The elemental iron product used is Iron sucrose 20 mg/mL. Iron deficiency anemia is the type of anemia caused by iron depletion. It is important to note that the above calculations merely provide estimates and that individual dosage should be established by a medical professional based on the current package insert for the elemental iron product used. Use Caution/Monitor. The dosage of Venofer is expressed in mg of elemental iron. 2.1 Dosage - Total dose infusion The dose calculation for CosmoFer is based on patients body weight according to the table below and is diluted in 500mLs of normal saline. Applies only to oral form of both agents. Use Caution/Monitor. 2 DOSAGE AND ADMINISTRATION 2.1 Recommended Dosage Recommended dosage for patients weighing 50kg (110lb) or more: Give Injectaferin two doses separated by at least 7 days. iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. Allow at least 30 minutes between administration of Feraheme and administration of other medications that could potentially cause serious hypersensitivity reactions and/or hypotension, such as chemotherapeutic agents or monoclonal antibodies. ONE DOSE. Hemodialysis-dependent: 0.5 mg/kg IV q2weeks for 12 weeks; not to exceed 100 mg/dose, Non-dialysis dependent or peritoneal-dependent (on erythropoietin): 0.5 mg/kg IV q4weeks for 12 weeks; not to exceed 100 mg/dose, sodium sulfate/?magnesium sulfate/potassium chloride, sodium sulfate/potassium sulfate/magnesium sulfate, Serious hypersensitivity reactions reported, including anaphylactic-type reactions, some of which have been life-threatening and fatal, Patients may present with shock, clinically significant hypotension, loss of consciousness, and/or collapse, If hypersensitivity reactions or signs of intolerance occur during administration, stop infusion immediately, Monitor patients for signs and symptoms of hypersensitivity during and after administration for at least 30 minutes and until clinically stable following completion of the infusion, Animal reproduction studies of iron sucrose administered to rats and rabbits during period of organogenesis at elemental iron doses equivalent to maximum recommended human dose based on body surface area revealed no evidence of harm to the fetus; adverse outcomes in pregnancy occur regardless of health of mother or use of medications, Iron deficiency anemia during pregnancy should be treated; untreated IDA in pregnancy is associated with adverse maternal outcomes such as post-partum anemia; adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight, HD-dependent and non-dialysis-dependent CKD: Dilute with up to 100 mL of 0.9% NaCl, PD-dependent CKD: Dilute with up to 250 mL of 0.9% NaCl, Undiluted: Administer by slow IV injection over 2-5 min, Diluted solutions: Administer IV over 15 min, Undiluted: Administer by slow IV injection over 5 minutes, Diluted solutions: Administer IV over 5-60 minutes, Store in original carton at 20-25C (68-77 F); excursions permitted to 15- 30C (59-86F), Syringe: Store at room temperature (25C) or under refrigeration (4C) for up to 7 days, IV infusion: Store at room temperature (25C) for up to 7 days. A: Generally acceptable. David McAuley, Pharm.D. Modify Therapy/Monitor Closely. Medicinal forms Serious - Use Alternative (1)iron sucrose decreases levels of minocycline by inhibition of GI absorption. Applies only to oral form of both agents. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores The recommendation is that most adults need a cumulative dose of elemental iron of at least 1 g.

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